PROTEIN BINDING OF PANCREATIC PROTEOLYTIC ENZYMES*

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Binding of Pancreatic Proteolytic Enzymes

In human serum there are two protein fractions that are potent inhibitors to trypsin. These inhibitors travel with the a1-globulin and a2-globulin fractions when serum proteins are separated by electrophoresis (1-3). One ml of normal serum has sufficient amounts of trypsin inhibitor to neutralize the proteolytic effect of 1.15 (± 0.10) mg of crystalline trypsin. Approximately 90 per cent of the...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1962

ISSN: 0021-9738

DOI: 10.1172/jci104576